Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
-20°C
Thrombin Inhibitor Screening Assay Kit (Fluorometric)
(ab197007) is an assay where the synthetic AMC-based peptide substrate provided
is proteolytically cleaved by Thrombin in order to release a fluorophore, AMC,
which can be easily quantified by fluorescence reader at Ex/Em = 350/450 nm. In
the presence of Thrombin specific inhibitors, the extent of cleavage reaction
is reduced or completely abolished. The loss in the fluorescence intensity can
be correlated to the amount of inhibitor present in the assay solution.
The kit provides a simple and rapid method to screen
potential inhibitors of thrombin and to characterize thrombin inhibitors found
in plasma samples.
This product is manufactured by BioVision, an Abcam company
and was previously called K374 Thrombin Inhibitor Screening Kit (Fluorometric).
K374-100 is the same size as the 100 test size of ab197007.
Thrombin enzyme (Factor IIa) is an important clotting factor
that controls the transformation of soluble fibrinogen to insoluble active
fibrin strands. Thrombin is a serine protease (EC 3.4.21.5) that catalyzes many
coagulation-related reactions. Thrombin inhibitors are used as anticoagulants
to prevent arterial and venous thrombosis. Some of these inhibitors are
currently in clinical use while others are in clinical development.
The Safety Datasheet for this product has been updated for
certain countries. Please check the current version in the Support and
downloads section.
